Oligoribonucleotide synthesis by the use of 1-(2-cyanoethoxy) ethyl (CEE) as a 2′-hydroxy protecting group

T Umemoto, T Wada

Index: Umemoto, Tadashi; Wada, Takeshi Tetrahedron Letters, 2004 , vol. 45, # 52 p. 9529 - 9531

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Citation Number: 27

Abstract

A novel method for the synthesis of oligoribonucleotides using 1-(2-cyanoethoxy) ethyl (CEE) as a 2′-hydroxy protecting group has been developed. A CEE group was introduced to the 2′-position of N-acyl-3′, 5′-O-silyl-protected ribonucleosides under acidic conditions in good yields. The 2′-O-CEE group was found to be stable in an aqueous or ethanolic ammonia and was quickly removed by treatment with anhydrous ...