Generation and Trapping of o-Thioquinones on Solid Support: Synthesis of Hydroxylated 4-Thiaflavans

S Menichetti, C Viglianisi

Index: Menichetti, Stefano; Viglianisi, Caterina Phosphorus, Sulfur and Silicon and the Related Elements, 2009 , vol. 184, # 5 p. 1233 - 1246

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Abstract

The generation and trapping of o-thioquinones was successfully applied to the synthesis of hydroxy-4-thiaflavans on solid support using commercially available carboxy and aminomethylated polystyrene resins. These valuable cycloadducts are obtained as pure compounds without any intermediate purification, in better overall yields than the solution phase procedure.