Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies

L Trzoss, J Xu, MH Lacoske, WC Mobley…

Index: Trzoss, Lynnie; Xu, Jing; Lacoske, Michelle H.; Mobley, William C.; Theodorakis, Emmanuel A. Chemistry - A European Journal, 2013 , vol. 19, # 20 p. 6398 - 6408

Full Text: HTML

Citation Number: 28

Abstract

Abstract Majucin-type sesquiterpenes from Illicium sp., such as jiadifenolide (2), jiadifenin (3), and (1R, 10S)-2-oxo-3, 4-dehydroxyneomajucin (4, ODNM), possess a complex caged chemical architecture and remarkable neurotrophic activities. As such, they represent attractive small-molecule leads against various neurodegenerative diseases. We present an efficient, enantioselective, and unified synthesis of 2, 3, and 4 and designed analogues ...

Related Articles:

Divergent Total Syntheses of (−)-Lycopladine D,(+)-Fawcettidine, and (+)-Lycoposerramine Q

[Zeng, Chen; Zheng, Changwu; Zhao, Jingyun; Zhao, Gang Organic Letters, 2013 , vol. 15, # 22 p. 5846 - 5849]

Benzimidazole??pyrrolidine/H+ (BIP/H+), a Highly Reactive Organocatalyst for Asymmetric Processes

[Lacoste, Eric; Vaique, Emilie; Berlande, Muriel; Pianet, Isabelle; Vincent, Jean-Marc; Landais, Yannick European Journal of Organic Chemistry, 2007 , # 1 p. 167 - 177]

Benzimidazole??pyrrolidine/H+ (BIP/H+), a Highly Reactive Organocatalyst for Asymmetric Processes

[Lacoste, Eric; Vaique, Emilie; Berlande, Muriel; Pianet, Isabelle; Vincent, Jean-Marc; Landais, Yannick European Journal of Organic Chemistry, 2007 , # 1 p. 167 - 177]

Benzimidazole??pyrrolidine/H+ (BIP/H+), a Highly Reactive Organocatalyst for Asymmetric Processes

[Lacoste, Eric; Vaique, Emilie; Berlande, Muriel; Pianet, Isabelle; Vincent, Jean-Marc; Landais, Yannick European Journal of Organic Chemistry, 2007 , # 1 p. 167 - 177]

More Articles...