Anticonvulsant activity of some 4-aminobenzamides

CR Clark, MJM Wells, RT Sansom…

Index: Clark; Wells; Sansom; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 779 - 782

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Citation Number: 73

Abstract

A series of 4-aminobenzamides of some simple primary and secondary amines were prepared and evaluated for anticonvulsant effects. The compounds were tested in mice against seizures induced by electroshock and p8ntylenetetrazole (metrazole) and in the rotorod assay for neurologic deficit. For those N-alkyl amides tested, 4-amino-N- amylbenzamide (6) was the most potent against maximal electroshock seizures (MES): ...