Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles

…, ES Furfine, RJ Hazen, I Kaldor, D Reynolds…

Index: Miller, John F.; Brieger, Michael; Furfine, Eric S.; Hazen, Richard J.; Kaldor, Istvan; Reynolds, David; Sherrill, Ronald G.; Spaltenstein, Andrew Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 15 p. 3496 - 3500

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Citation Number: 17

Abstract

A novel series of tyrosine-derived HIV protease inhibitors was synthesized and evaluated for in vitro antiviral activity against wild-type virus and two protease inhibitor-resistant viruses. All of the compounds had wild-type antiviral activities that were similar to or greater than several currently marketed HIV protease inhibitors. In addition, a number of compounds in this series were more potent against the drug-resistant mutant viruses than they were ...