Synthesis and antimicrobial activity of pyrazole-4-carboxylic acid hydrazides and N-(4-pyrazoyl) hydrazones of aromatic and heteroaromatic aldehydes

VA Chornous, MK Bratenko, MV Vovk…

Index: Chornous; Bratenko; Vovk; Sidorchuk Pharmaceutical Chemistry Journal, 2001 , vol. 35, # 4 p. 203 - 205

Full Text: HTML

Citation Number: 28

Abstract

Proceeding from the fact that some widely used antibacterial preparations (furacilin, furazolidone, ftivazide) contain hydrazone groups, we decided to synthesize a series of pyrazole-4-carboxylic acid hydrazides, modify these compounds so as to obtain N-(4- pyrazoyl) hydrazones, and study the antibacterial properties of the products. Hydrazides IIIa– IIIg were synthesized based on the previously described pyrazole-4-carboxylic ...