In Situ Generation of PhI+ CF3 and Transition??Metal??Free Oxidative sp2 C H Trifluoromethylation

…, J Liu, W Ming, Y Liu, J Liu, M Wang…

Index: Xu, Cong; Liu, Jingxin; Ming, Wenbo; Liu, Yingjie; Liu, Jun; Wang, Mang; Liu, Qun Chemistry - A European Journal, 2013 , vol. 19, # 28 p. 9104 - 9109

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Citation Number: 38

Abstract

Approximately 20–30% of modern pharmaceuticals and agrochemicals contain fluorine atoms, because fluorinated compounds are more difficult to oxidize, leading to increased metabolic stability and bioavailability over their non-fluorinated analogues.[1] As a consequence, rapidly increasing efforts have focused on developing valuable strategies, reagents, and catalysts for the incorporation of, for example, CF3 into various organic ...

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