Palladium (II)-catalyzed cyclization of olefinic tosylamides

…, TR Hightower, LA Hasvold, KP Peterson

Index: Larock, Richard C.; Hightower, Timothy R.; Hasvold, Lisa A.; Peterson, Karl P. Journal of Organic Chemistry, 1996 , vol. 61, # 11 p. 3584 - 3585

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Citation Number: 221

Abstract

The palladium-catalyzed cyclization of simple olefinic amines, 1 tosylamides, 2 and carboxamides3 has proven to be a particularly valuable route to a wide variety of nitrogen heterocycles. For example, the cyclization of o-vinylic1d, h, 2b, f and o-allylic1cre, h anilines or their tosyl derivatives by either stoichiometric amounts of palladium (II) salts or catalytic amounts of palladium (II) salts in the presence of benzoquinone as a reoxidant efficiently ...