Synthesis and antihypertensive activity of 2, 4-dioxoimidazolidin-1-yl and perhydro-2, 4-dioxopyrimidin-1-yl ergoline derivatives
S Mantegani, E Brambilla, C Caccia, L Chiodini…
Index: Mantegani, Sergio; Brambilla, Enzo; Caccia, Carla; Chiodini, Laura; Ruggieri, Daniela; Lamberti, Ernesto; Di Salle, Enrico; Salvati, Patricia Farmaco, 1998 , vol. 53, # 4 p. 293 - 304
Full Text: HTML
Citation Number: 10
Abstract
The synthesis and antihypertensive activity of a series of 2, 4-dioxoimidazolidin-1-yl and perhydro-2, 4-dioxopyrimidin-1-yl ergoline derivatives are reported. The oral antihypertensive activity was studied in spontaneously hypertensive rats (SHRs) by measuring systolic blood pressure by an indirect tail-cuff method at different times after treatment. The prolactin lowering activity (indirectly measured by the nidation test) in rats ...
Related Articles:
[Smidrkal; Semonsky Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 2 p. 625 - 629]
[Smidrkal; Semonsky Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 2 p. 625 - 629]
[Smidrkal; Semonsky Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 2 p. 625 - 629]