Preparations of melatonin and 1-hydroxymelatonin, and its novel nucleophilic dimerization to (±)-3a, 3a'-bispyrrolo [2, 3-b] indoles

…, N Oshikiri, M Hasegawa, F Yamada

Index: Somei, Masanori; Oshikiri, Naoki; Hasegawa, Masakazu; Yamada, Fumio Heterocycles, 1999 , vol. 51, # 6 p. 1237 - 1242

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Citation Number: 23

Abstract

抄録: A unique synthetic method for melatonin was established through biologically promising synthetic intermediates. 1-Hydroxymelatonin was prepared as crystals for the first time. It reacted with 85% formic acid to give (±)-3a, 3a'-bispyrrolo [2, 3-b] indole compound, whose structure was unequivocally determined by X-Ray crystallographic analysis