Tetrahedron

Enantio-and diastereoselective catalysis of addition reaction of allylic silanes and stannanes to glyoxylates by binaphthol-derived titanium complex

S Aoki, K Mikami, M Terada, T Nakai

Index: Aoki, Seiichi; Mikami, Koichi; Terada, Masahiro; Nakai, Takeshi Tetrahedron, 1993 , vol. 49, # 9 p. 1783 - 1792

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Citation Number: 120

Abstract

Chiral titanium complex (1), prepared in situ from optically pure binaphthol and diisopropoxytitanium dihalide in the presence of molecular sieves, is shown to catalyze the addition reactions of crotylsilanes and-stannanes to glyoxylates to afford (syn)-α-hydroxy-β- methyl esters in highly scalemic forms with high diastereoselectivity.

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