The Journal of organic chemistry

Synthesis of Cyclo-2, 2': 4', 4'': 2'', 2''': 4''', 4'''': 2'''', 2''''': 4''''', 4-sexipyridine

TR Kelly, YJ Lee, RJ Mears

Index: Kelly, T. Ross; Lee, Yean-Jang; Mears, Richard J. Journal of Organic Chemistry, 1997 , vol. 62, # 9 p. 2774 - 2781

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Citation Number: 50

Abstract

Preparation of the title compound (2) by use of Stille couplings and a Kröhnke pyridine synthesis is described. By application of the Stille coupling reaction, preparation and functionalization of quater-and quinquepyridines 26, 27, and 28 were achieved. Elaboration of quinquepyridine 27 to the pyridinium salt 30 bearing a protected enal allowed for the synthesis of 2 by a one-pot deprotection/Kröhnke reaction in nine steps from 4, 4'- ...