Organic & biomolecular chemistry

Simplified dynemicin analogues: diastereoselective synthesis and evaluation of their activity against plasmid DNA

G Guanti, R Riva

Index: Guanti, Giuseppe; Perrozzi, Sara; Riva, Renata Tetrahedron Asymmetry, 2002 , vol. 13, # 24 p. 2703 - 2706

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Citation Number: 16

Abstract

The total synthesis of two diastereoisomeric simplified dynemicin analogues is reported. The key steps involved are: the regio-and diastereoselective functionalisation of an appropriate racemic quinoline precursor and the ring closure to give the 10-membered enediyne moiety

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