Synthesis of deuterium-and tritium-labeled 4-methoxy-6-amino-pyrimido [4, 5, b](1, 4)-thiazine hydrochloride

V Yadrovskaya, MP Nemeryuk, TS Safonova

Index: Yadrovskaya, V.; Nemeryuk, M. P.; Safonova, T. S. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 6 p. 518 - 521 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 6 p. 730 - 733

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Abstract

The reaction of compound VIII with chloroacetonitrile was carried out in Me0H or in ethanol in the presence of alkali, after first ascertaining that no exchange of deuterium for protons took place under these conditions and no transesterification of the OCD 3 group was