Organic letters

A general, Brønsted acid-catalyzed hetero-Michael addition of nitrogen, oxygen, and sulfur nucleophiles

TC Wabnitz, JB Spencer

Index: Wabnitz, Tobias C.; Spencer, Jonathan B. Organic Letters, 2003 , vol. 5, # 12 p. 2141 - 2144

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Citation Number: 202

Abstract

Strong Brønsted acids such as bis (trifluoromethanesulfon) imide catalyze the hetero- Michael addition of carbamates, alcohols, and thiols to α, β-unsaturated ketones, alkylidene malonates, and acrylimides. Scope, reaction rates, and yields are superior to comparable Lewis acid-catalyzed processes.

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