Michaelis-Becker synthesis of bis (2, 2, 2-trifluoroethyl) phosphono esters

GM Ciszewski, JA Jackson

Index: Ciszewski, Gregory M.; Jackson, John A. Organic Preparations and Procedures International, 1999 , vol. 31, # 2 p. 240 - 243

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Citation Number: 7

Abstract

The Michaelis-Becker reaction is a well known method for the synthesis of alkylphosphonates,'although the yields of phosphono esters tend to be relatively 10w. l'Although the Arbuzov reaction generally provides phosphono esters in significantly higher yields," bis (2, 2, 2-trifluoroethy1) phosphono esters are inaccessible via the Arbuzov reaction due to the non-nucleophilic nature of (CF3CH, 0) 3P. bis (2, 2, 2-Trifluoroethyl) ...