Tetrahedron letters

Synthesis of oligodeoxyribonucleotides containing 5′-aminoalkylphosphonates

VK Kansal, T Huynh-Dinh, J Igolen

Index: Kansal, Vinod K.; Huynh-Dinh, Tam; Igolen, Jean Tetrahedron Letters, 1988 , vol. 29, # 43 p. 5537 - 5540

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Citation Number: 12

Abstract

Abstract A simple synthesis of oligodeoxyribonucleotides possessing 5′- aminoalkylphosphonate both in solution and on solid support is reported. These oligonucleotides have been reacted with the N-hydroxysuccinimide ester of d-biotin and fluoresceine isothiocyanate to give biotinylated and fluoresceinylated oligonucleotides.