Tetrahedron letters

Asymmetric synthesis of polymer-supported cyanohydrin acetates

YN Belokon, P Carta, M North

Index: Belokon', Yuri N.; Carta, Paola; North, Michael Tetrahedron Letters, 2005 , vol. 46, # 26 p. 4483 - 4486

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Citation Number: 12

Abstract

Over the last eight years, we have developed bimetallic titanium(salen) complex 1 as a highly enantioselective and remarkably versatile catalyst for the asymmetric addition of various cyanide sources to aldehydes 1 and ketones. 2 Catalyst 1 will induce the asymmetric addition of trimethylsilyl cyanide, 3 potassium cyanide/an anhydride 4 and ethyl cyanoformate 4c and 5 to aldehydes, providing access to non-racemic cyanohydrin trimethylsilyl ethers, ...