A novel antibacterial 8-chloroquinolone with a distorted orientation of the N1-(5-amino-2, 4-difluorophenyl) group

…, Y Ohshita, J Yoshida, A Yazaki, M Shiro…

Index: Renau, Thomas E.; Sanchez, Joseph P.; Domagala, John M. Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 4 p. 1407 - 1411

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Citation Number: 40

Abstract

... Journal of Medicinal ... to Schemes 1−5. Scheme 1 shows the preparation of N-1 substituents, tert-butyl aminophenylcarbamates 7a−e. The intermediates, m-nitrobenzoic acids, were ... 19 Applying this method to the reaction of 13d,e with 3-aminoazetidine did not improve the yield. ...