Polystyrene-based deblocking-scavenging agents for the 9-fluorenylmethyloxycarbonyl amino-protecting group

…, EME Mansour, CH Cheng, JR Williams…

Index: Carpino, Louis A.; Mansour, E. M. E.; Cheng, C. H.; Williams, James R.; MacDonald, Russell; et al. Journal of Organic Chemistry, 1983 , vol. 48, # 5 p. 661 - 665

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Citation Number: 60

Abstract

Piperazino-and piperidino-functionalized polystyrenes have been examined as deblocking- scavenging agents for the 9-fluorenylmethyloxycarbonyl (Fmoc) amino-protecting group. Both commercial and synthesized polystyrenes have been used as supports. In order to introduce the active functional groups,(chloromethy1)-polystyrene 2 was treated with tert- butyl piperazine-1-carboxylate followed by acidic deblocking (HCl/dioxane) or, ...

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