Synthesis and biological activities of substance P antagonists

S Caranikas, J Mizrahi, E Escher…

Index: Caranikas, S.; Mizrahi, J.; Escher, E.; Regoli, D. Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1313 - 1316

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Citation Number: 18

Abstract

Several substance P analogues containing various D-amino acid modifications have been synthesized by the solid-phase procedure, detached from the solid support by ammonolysis, and purified by gel filtration combined with reversed-phase chromatography. Three compounds were fair to very potent competitive antagonisb of substance P on three bioassays, Le., guinea pig ileum, rabbit mesenteric vein, and guinea pig trachea.[Args,~- ...