Tetrahedron letters

Facile preparation of 3′ oligonucleotide-peptide conjugates

CD Juby, CD Richardson, R Brousseau

Index: Juby, Carl D.; Richardson, Christopher D.; Brousseau, Roland Tetrahedron Letters, 1991 , vol. 32, # 7 p. 879 - 882

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Citation Number: 79

Abstract

Abstract The solid phase synthesis of 3′ deoxyoligonucleotide (17 mer)-peptide conjugates is described. The oligonucleotide is complementary to the template strand of the measles virus in the region of the nucleocapsid protein on the 60 nucleotide leader RNA. The conjugates were synthesized on teflon support using a combination of solid phase FMOC peptide chemistry and phosphoramidite chemistry linked by a branched modifier.