Thiophenesulfonamides as endothelin receptor antagonists

…, A Kois, E Verner, I Okun, F Stavros, MF Chan

Index: Raju; Wu, Chengde; Kois, Adam; Verner, Erik; Okun, Ilya; Stavros, Fiona; Chan, Ming Fai Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 22 p. 2651 - 2656

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Citation Number: 28

Abstract

(a) To a stirred solution of 3-bromothiophene (1.5 g, 9.2 mmol) in dry ether (15 mL) at −78 °C was added t-BuLi (5.95 mL of 1.7 M in hexane, 10 mmol) dropwise. The reaction mixture was stirred at −78 °C for 30 min. Sulfur dioxide gas was bubbled in slowly for 10 min and the reaction mixture was allowed to attain room temperature slowly. N-Chlorosuccinimide (1.51 g, 11.4 mmol) was added and after 1 h the reaction mixture was diluted with water and extracted ...

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