Assembly of Substituted Phenothiazines by a Sequentially Controlled CuI/L??Proline??Catalyzed Cascade C S and C N Bond Formation

D Ma, Q Geng, H Zhang, Y Jiang

Index: Dawei, Ma.; Geng, Qian; Zhang, Hui; Jiang, Yongwen Angewandte Chemie - International Edition, 2010 , vol. 49, # 7 p. 1291 - 1294

Full Text: HTML

Citation Number: 80

Abstract

The phenothiazine structural motif has been successfully employed in the design of a variety of pharmaceuticals. Successful examples include promazine drugs (1a–c), which are clinically used for psychotropic medication;[1] quaternized trifluoropromazine derivative 2 that has antitubercular activity;[2] cholinesterase inhibitor 3;[3] histamine H1 antagonist 4;[4] and MDR (multiple drug resistance) reverting agent 5.[5] Substituted phenothiazines have ...

Related Articles:

Unexpectedly ligand-free copper-catalyzed C–S cross-coupling of benzothiazole with aryl iodides in aqueous solution

[Feng, Yi-Si; Qi, Hong-Xia; Wang, Wei-Cheng; Liang, Yu-Feng; Xu, Hua-Jian Tetrahedron Letters, 2012 , vol. 53, # 23 p. 2914 - 2917]

Copper Oxide Nanoparticles Supported on Graphene Oxide??Catalyzed S??Arylation: An Efficient and Ligand??Free Synthesis of Aryl Sulfides

[Kamal, Ahmed; Srinivasulu, Vunnam; Murty; Shankaraiah, Nagula; Nagesh, Narayana; Reddy, T. Srinivasa; Subba Rao Advanced Synthesis and Catalysis, 2013 , vol. 355, # 11-12 p. 2297 - 2307]

A GENERAL PRINCIPLE FOR THE SYNTHESIS OF HETEROCYCLIC AND HOMOCYCLIC COMPOUNDS1

[Hrutford; Bunnett Journal of the American Chemical Society, 1958 , vol. 80, p. 2021]

Copper Oxide Nanoparticles Supported on Graphene Oxide??Catalyzed S??Arylation: An Efficient and Ligand??Free Synthesis of Aryl Sulfides

[Kamal, Ahmed; Srinivasulu, Vunnam; Murty; Shankaraiah, Nagula; Nagesh, Narayana; Reddy, T. Srinivasa; Subba Rao Advanced Synthesis and Catalysis, 2013 , vol. 355, # 11-12 p. 2297 - 2307]

Ring Closure via Aryne Intermediates: A General Principle of Synthesis1, 2

[Bunnett,J.F.; Hrutfiord,B.F. Journal of the American Chemical Society, 1961 , vol. 83, p. 1691 - 1697]

More Articles...