Synthesis and pharmacological activity of 1-phenoxy-3-aminopropanol-2-derivatives

OM Glozman, EK Orlova, ÉS Agavelyan…

Index: Glozman, O. M.; Orlova, E. K.; Agavelyan, E. S.; Ismailov, Sh. I.; Nerobkova, L. N.; et al. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 3 p. 197 - 200 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 3 p. 309 - 312

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Abstract

As a continuation of studies [3, 4] concerned with the search for new effective $-adrenergic blockers and structure-action relationships, we synthesized homologs of a! prenolol which differs from many B-adrenergic blockers in its less pronounced internal sympathomimetic activity which leads to myocardial suppression [9, ii]. In order to study the effect of the methyl group in the meta-and para-positions relative to the side aminopropanol group in the ...