Synthetic Communications

Regiospecific Synthesis of Trimethylsilyl Enol Ethers

GM Rubottom, RC Mott, DS Krueger

Index: Rubottom,G.M. et al. Synthetic Communications, 1977 , vol. 7, p. 327 - 332

Full Text: HTML

Citation Number: 22

Abstract

Abstract Continuing interest in the use of trimethylsilyl enol ethers 1 as synthetic intermediates, 1 has prompted efforts toward developing efficient, regiospecific methods for the preparation of these versatile compounds. In general, silylation of enolate anions with chlorotrimethyl silane (CTMS) has proven to be the procedure most widely used. 2, 3, 4 In the case of unsymmetrical ketones such as 2,(Table 1) the use of strong base (LDA)(entry ...