Tetrahedron letters

2, 3-Disubstituted pyrrolo [2, 3-b] quinoxalines via aminopalladation–reductive elimination

A Arcadi, S Cacchi, G Fabrizi, LM Parisi

Index: Arcadi, Antonio; Cacchi, Sandro; Fabrizi, Giancarlo; Parisi, Luca M. Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2431 - 2434

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Citation Number: 23

Abstract

The quinoxaline nucleus is present in many pharmaceutical agents exhibiting a broad spectrum of biological activities such as antiviral, 1 antiglucoma, 2 and anticancer 3 activity. Recently, novel pyrrolo[1,2-a]quinoxalines have been proved to be potent and selective 5-HT 3 receptor ligands. 4 Because of this, a variety of conventional methods have been developed for the preparation of quinoxaline derivatives. 5 A solid-phase synthesis of quinoxalines has also been ...

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