Potential Anticancer Agents. 1 XLII. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. III. An Improved Synthesis of 5, 8-Dideaza-5, 6, 7, 8-tetrahydrofolic Acid

JI DeGRAW, L GOODMAN…

Index: DeGraw,J.I. et al. Journal of Organic Chemistry, 1961 , vol. 26, p. 1156 - 1161

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Citation Number: 31

Abstract

The conversion of 4oxocyclohexanecarboxaldehyde dimethyl acetal (VIII) to 2-acetamid0-5, 6, 7, 8-tetrahydro-Phydroxy-6-quinazolinecarboxaldehyde (XIV) provided the key intermediate for an improved synthesis of 5, 8-dideaza-5, 6, 7, 8-tetrahydrofolic acid (I). The transformation of XIV to I wm accomplished either by the direct reductive alkyla, tion of p aminobenzoyl-cglutamic acid with XIV, followed by hydrolysis, or by the preparation of p [( ...

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