Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src

PA Plé, TP Green, LF Hennequin…

Index: Journal of Medicinal Chemistry, , vol. 47, # 4 p. 871 - 887

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Citation Number: 171

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. Most of the anilinoquinazolines (1−6, 8−24) described here were prepared as shown in Scheme 1. The basic side chain in the C-7 position of the quinazoline was generally ...