Au-and Pt-catalyzed cycloisomerizations of 1, 5-enynes to cyclohexadienes with a broad alkyne scope

…, MP Conley, L Zhang, SA Kozmin

Index: Sun, Jianwei; Conley, Matthew P.; Zhang, Liming; Kozmin, Sergey A. Journal of the American Chemical Society, 2006 , vol. 128, # 30 p. 9705 - 9710

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Citation Number: 129

Abstract

We describe the development of gold-and platinum-catalyzed cycloisomerizations of 1, 5- enynes. This catalytic process displays a wide alkyne scope and furnishes a range of highly functionalized 1, 4-and 1, 3-cyclohexadienes. In the case of 1-siloxy-1-yne-5-enes, the reactions are efficiently catalyzed by AuCl (1 mol%) at ambient temperature to afford siloxy cyclohexadienes or the corresponding 1, 2-and 1, 3-cyclohexenones upon subsequent ...