Enzymatic synthesis of enantiomerically pure β??amino ketones, β??amino esters, and β??amino alcohols with Baeyer–Villiger monooxygenases

J Rehdorf, MD Mihovilovic, MW Fraaije…

Index: Rehdorf, Jessica; Mihovilovic, Marko D.; Fraaije, Marco W.; Bornscheuer, Uwe T. Chemistry - A European Journal, 2010 , vol. 16, # 31 p. 9525 - 9535

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Citation Number: 22

Abstract

Abstract The enzymatic kinetic resolution of a broad set of β-amino ketones was investigated by using a collection of 16 Baeyer–Villiger monooxygenases from different bacterial origins, which display various substrate specificities. Within this platform of enzymes excellent enantioselectivities (E> 200) were found towards aliphatic and aromatic 4-amino-2-ketones, and some enzymes even showed opposite enantioselectivity. The intermediate β- ...