Simple o-quinodimethane route to (.+-.)-4-demethoxydaunomycinone

…, RJ Ardecky, MV Lakshmikantham…

Index: Kerdesky, Francis A.; Ardecky, Robert J.; Lakshmikantham, M. V.; Cava, Michael P. Journal of the American Chemical Society, 1981 , vol. 103, # 8 p. 1992 - 1996

Full Text: HTML

Citation Number: 71

Abstract

Abstract: The anthracycline antibiotics daunorubicin and adriamycin are important clinically useful drugs in the treatment of a number of human cancers. The structurally simplified synthetic analogues 4-demethoxydaunorubicin and 4-demethoxyadriamycin show much clinical promise. The synthesis of the corresponding aglycone (*)-4- demethoxydaunomycinone from the inexpensive dye intermediate quinizarin, utilizing o- ...

Related Articles:

Facile Total Syntheses of Idarubicinone??7?螃漫?D??glucuronide: Convenient Preparations of AB??Ring Synthon Using Some Carboxylic Acid Derivatives

[Rho, Young S.; Park, Jihyung; Kim, Gyuil; Kim, Hyesun; Sin, Hongsig; Suh, Pyoung Won; Yoo, Dong Jin Synthetic Communications, 2004 , vol. 34, # 9 p. 1703 - 1722]

A novel synthesis of the. ALPHA.-hydroxyketone moiety of anthracyclinones by the use of 2-trimethylsilylethynylcerium (III) reagents.

[Suzuki, Michiyo; Kimura, Yoshikazu; Terashima, Shiro Chemistry Letters, 1984 , p. 1543 - 1546]

Facile Total Syntheses of Idarubicinone??7?螃漫?D??glucuronide: Convenient Preparations of AB??Ring Synthon Using Some Carboxylic Acid Derivatives

[Rho, Young S.; Park, Jihyung; Kim, Gyuil; Kim, Hyesun; Sin, Hongsig; Suh, Pyoung Won; Yoo, Dong Jin Synthetic Communications, 2004 , vol. 34, # 9 p. 1703 - 1722]

An unusually simple route to 4-demethoxy-7-deoxydaunomycinone

[Lakshmikantham; Ravichandran; Gosciniak; Cava Tetrahedron Letters, 1985 , vol. 26, # 39 p. 4703 - 4706]

Perylenequinone Natural Products: Enantioselective Synthesis of the Oxidized Pentacyclic Core†

[Broadhurst, Michael J.; Hassall, Cedric H.; Thomas, Gareth J. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 9 p. 2239 - 2248]

More Articles...