European journal of medicinal chemistry

Synthesis and in vitro cytotoxic activity of pyrrolo [2, 3-e] indole derivatives and a dihydro benzoindole analogue

L Chacón-Garcı́a, R Martı́nez

Index: Chacon-Garcia, Luis; Martinez, Roberto European Journal of Medicinal Chemistry, 2002 , vol. 37, # 3 p. 261 - 266

Full Text: HTML

Citation Number: 24

Abstract

The synthesis of pyrrolo [2, 3-e] indole derivatives with the structural characteristics of DNA bis-and mono-intercalators are described. A dihydro benzoindol analogue was also synthesised to elucidate the major structural requirements for cytotoxic activity. A biological evaluation of the test compounds was carried out in six different tumoral cell lines. The factors that affect the cytotoxic activity appear to be the substituents on the phenyl group, ...

Related Articles:

Origin of the preference for the chair conformation in the Cope rearrangement. Effect of phenyl substituents on the chair and boat transition states

[Shea; Stoddard; England; Haffner Journal of the American Chemical Society, 1992 , vol. 114, # 7 p. 2635 - 2643]

Oxidative Carbon− Carbon Bond Formation via Allyldimethylsilyl Enol Ethers

[Konkol, Leah C.; Jones, Brian T.; Thomson, Regan J. Organic Letters, 2009 , vol. 11, # 23 p. 5550 - 5553]

The case favoring direct C-alkylation of heteroatom-substituted enolates

[Solomon, Mark; Hoekstra, William; Zima, George; Liotta, Dennis Journal of Organic Chemistry, 1988 , vol. 53, # 21 p. 5058 - 5062]

Low-valent zirconocene-mediated cyclization of γ, δ-unsaturated oximes

[Kitamura, Mitsuru; Shintaku, Yuki; Kudo, Daisuke; Okauchi, Tatsuo Tetrahedron Letters, 2010 , vol. 51, # 37 p. 4890 - 4893]

The case favoring direct C-alkylation of heteroatom-substituted enolates

[Solomon, Mark; Hoekstra, William; Zima, George; Liotta, Dennis Journal of Organic Chemistry, 1988 , vol. 53, # 21 p. 5058 - 5062]

More Articles...