Novel and highly potent histamine H3 receptor ligands. Part 1: withdrawing of hERG activity

…, O Poupardin-Olivier, I Berrebi-Bertrand…

Index: Levoin, Nicolas; Labeeuw, Olivier; Calmels, Thierry; Poupardin-Olivier, Olivia; Berrebi-Bertrand, Isabelle; Lecomte, Jeanne-Marie; Schwartz, Jean-Charles; Capet, Marc Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5378 - 5383

Full Text: HTML

Citation Number: 13

Abstract

Pre-clinical investigation of some aryl-piperidinyl ether histamine H3 receptor antagonists revealed a strong hERG binding. To overcome this issue, we have developed a QSAR model specially dedicated to H3 receptor ligands. This model was designed to be directly applicable in medicinal chemistry with no need of molecular modeling. The resulting recursive partitioning trees are robust (80–85% accuracy), but also simple and ...