Reactions with thioethoxide ion in dimethylformamide. I. Selective demethylation of aryl methyl ethers

GI Feutrill, RN Mirrington

Index: Feutrill,G.I.; Mirrington,R.N. Australian Journal of Chemistry, 1972 , vol. 25, p. 1719 - 1729

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Citation Number: 102

Abstract

Abstract Recent methods for demethylating aryl methyl ethers have been briefly reviewed, especially methods involving the use of nucleophilic reagents. Sodium thioethoxide dissolved in N, N-dimethylformamide has been developed as a powerful new reagent for demethylating aryl methyl ethers cleanly and rapidly in high yield. The reaction conditions can be controlled so that aromatic bromo substituents or isolated olefinic bonds are ...