Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 1. Substituted benzenedisulfonamides

PE Cross, B Gadsby, GF Holland…

Index: Cross,P.E. et al. Journal of Medicinal Chemistry, 1978 , vol. 21, p. 845 - 850

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Citation Number: 16

Abstract

As a consequence of the overall aging of the population, cerebrovascular disease is becoming a major medical and social problem. There is, therefore, an urgent need to discover an effective therapy to improve the function of the aging brain. It is well established that the degree and extent of the neurological deficit correlate with decreases in both cerebral blood flow and oxygen~ tilization,'-~ but it is not certain which constitutes the ...