. alpha.-Ethynyl and. alpha.-vinyl analogs of ornithine as enzyme-activated inhibitors of mammalian ornithine decarboxylase

C Danzin, P Casara, N Claverie…

Index: Danzin; Casara; Claverie; Metcalf Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 16 - 20

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Citation Number: 47

Abstract

Centre de Recherche Merrell International, 67084 Strasbourg CEder, France. Received July 1, 1980 a-Ethynyl-and a-vinylomithine were designed and synthesized as potential enzymeactivated inhibitors of" ah'an ornithine decarboxylase. These two new inhibitors produce both immediate and time-dependent inhibition of rat liver ornithine decarboxylase in vitro. The inhibitions exhibit saturation kinetics. The apparent dissociation constanta (Kr) ...