Synthesis, preliminary structure–activity relationships, and in vitro biological evaluation of 6-aryl-3-amino-thieno [2, 3-b] pyridine derivatives as potential anti- …

…, B Wang, HY He, JY Liu, ML Xiang, J He, XH Wu…

Index: Liu, Huan; Li, Yi; Wang, Xiang-Ying; Wang, Bo; He, Hai-Yun; Liu, Ji-Yan; Xiang, Ming-Li; He, Jun; Wu, Xiao-Hua; Yang, Li Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 8 p. 2349 - 2352

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Citation Number: 19

Abstract

In our previous study, a series of 6-aryl-3-amino-thieno [2, 3-b] pyridine derivatives exhibited potent antiproliferative activities and an unique hepatocellular carcinoma (HCC)-specific anticancer activity was also observed. In further anti-inflammatory research, thienopyridine derivative 1a showed potent inhibition of nitric oxide (NO) production. So a series of thienopyridine analogues of 1a were synthesized and evaluated for anti-inflammatory ...