Development of synthetic routes to macrocyclic compounds based on the HSP90 inhibitor radicicol

…, TS Cooper, P Sheldrake, P Workman, E McDonald

Index: Atrash, Butrus; Cooper, Tracey S.; Sheldrake, Peter; Workman, Paul; McDonald, Edward Tetrahedron Letters, 2006 , vol. 47, # 13 p. 2237 - 2240

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Citation Number: 10

Abstract

... Sonogashira 8 coupling of methyl 2-iodo-benzoate (3, R 3 = H) and pentyn-5-ol (5, n = 1) in degassed piperidine 9 mediated by tetrakis(triphenylphosphine)palladium(0) and copper iodide gave the desired product 7 in 86% yield. ... 6; B. Dymock, X. Barril, P. Brough, J. Cansfield, A. Massey, E. McDonald, R. Hubbard, A. Surgenor, S. Roughley, P. Webb, P. Workman, L. Wright, M. Drysdale; J. Med. Chem., 48 (2005), pp. 4212–4215. ...