Synthesis and antimalarial activity of a new series of trioxaquines

C Singh, H Malik, SK Puri

Index: Singh, Chandan; Malik, Heetika; Puri, Sunil K. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 1177 - 1182

Full Text: HTML

Citation Number: 66

Abstract

Trioxanes 8a–b, easily accessible in two steps from allylic alcohol 6a–b, on reductive amination with 4-aminoquinolines 4a–c furnish a new series of trioxaquines 9a–b, 10a–b, 11a–b in 32–77% yields. Dicitrate salts of these trioxaquines have been evaluated for antimalarial activity against multidrug resistant Plasmodium yoelii in mice model.