1, 3-Disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties

…, T Kasagami, C Morisseau, BD Hammock

Index: Kim, In-Hae; Tsai, Hsing-Ju; Nishi, Kosuke; Kasagami, Takeo; Morisseau, Christophe; Hammock, Bruce D. Journal of Medicinal Chemistry, 2007 , vol. 50, # 21 p. 5217 - 5226

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Citation Number: 56

Abstract

Soluble epoxide hydrolase (sEH) is a therapeutic target for treating hypertension and inflammation. 1, 3-Disubstituted ureas functionalized with an ether group are potent sEH inhibitors. However, their relatively low metabolic stability leads to poor pharmacokinetic properties. To improve their bioavailability, we investigated the effect of incorporating various polar groups on the ether function on the inhibition potencies, physical properties, ...