N-(Alkyl)-2-amino-1, 4-pyrazine derivatives: synthesis and antioxidative properties of 3-and 3, 5-p-hydroxyphenyl-substituted compounds

…, R Touillaux, JF Rees, J Marchand-Brynaert

Index: Bruyneel, Frederic; Marchand-Brynaert, Jacqueline Synlett, 2010 , # 13 p. 1974 - 1978

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Citation Number: 14

Abstract

Abstract 2-Amino-5-(p-hydroxyphenyl)-1, 4-pyrazine and 2-amino-3, 5-bis (p-hydroxyphenyl)- 1, 4-pyrazine are endowed with excellent antioxidative properties. For a possible development in medicinal chemistry, the lipophilicity of these lead compounds has to be increased. Therefore various methods of N-alkylation were systematically explored. The best results were obtained by quenching aminopyrazinyl anion with alkyl iodides, and by ...

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