Psychotomimetic N-methyl-N-isopropyltryptamines. Effects of variation of aromatic oxygen substituents

DB Repke, DB Grotjahn, AT Shulgin

Index: Repke, David B.; Grotjahn, Douglas B.; Shulgin, Alexander T. Journal of Medicinal Chemistry, 1985 , vol. 28, # 7 p. 892 - 896

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Citation Number: 25

Abstract

NJV-diethyl-4-hydroxy-DMT> NJV-diethyl-= 4-methoxy-DMT= 5-acetoxy-DMT> 6-methoxy- DMT> 7-methoxy-DMT. Our preliminary data" indicated that 4-hydroxy-N-methyl-N- isopropyltryptamine was orally active in man and was at least as potent as psilocin. The rank order of potency observed in a series of NJV-dialkyl-4-hydroxytryptamines was methyl, isopropyl> methyl, ethyl> methyl, methyl> methyl, n-propyl> ethyl, ethyl> isopropyl, ...

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