Stereo-and regioselective metal salt-catalyzed alkynylation of 1, 2-epoxides

M Chini, P Crotti, L Favero, F Macchia

Index: Chini; Crotti; Favero; Macchia Tetrahedron Letters, 1991 , vol. 32, # 45 p. 6617 - 6620

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Citation Number: 17

Abstract

Abstract A simple, efficient, stereoselective, and highly regioselective method for the synthesis of β-hydroxyacetylenes by the direct opening of 1, 2-epoxides with lithium acetylides in anhydrous THF, in the presence of metal salts, is described. This new method appears to be competitive and alternative to the other methods previously reported.