Tetrahedron letters

Organic-base-catalyzed synthesis of phthalides via highly regioselective intramolecular cyclization reaction

C Kanazawa, M Terada

Index: Kanazawa, Chikashi; Terada, Masahiro Tetrahedron Letters, 2007 , vol. 48, # 6 p. 933 - 935

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Citation Number: 54

Abstract

The organic-base-catalyzed 5-exo intramolecular cyclization reaction of o-alkynylbenzoic acid produces the corresponding phthalide regioselectively in good to excellent yields. The method provides a practical access to the phthalides, an important class of biologically active molecules.

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