European Journal of Organic Chemistry

Imidazole??Mediated Cascade [2+ 2+ 2] Annulation Reactions: A Highly Diastereoselective Synthetic Protocol for the Construction of Multiply Substituted …

XG Liu, M Shi

Index: Liu, Xu-Guang; Shi, Min European Journal of Organic Chemistry, 2008 , # 36 p. 6168 - 6174

Full Text: HTML

Citation Number: 6

Abstract

Abstract A novel imidazole-mediated [2+ 2+ 2] annulation process that enables the diastereoselective synthesis of multiply substituted cyclohexanes 3 in a one-pot, three- component manner from two units of (arylmethylidene) malononitriles 1 and one unit of nitroalkenes 2 is described. These cyclohexane derivatives were obtained in moderate to good yields under mild conditions.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 ...