Quantitative Structure-Activity Relationships in Cytokinin Agonistic and Antagonistic Pyrido [2, 3-d] pyrimidine Derivates: Insights into Receptor Topology

…, S Murakami, K Koshimizu, S Matsubara

Index: Iwamura, Hajime; Murakami, Shigeru; Koshimizu, Koichi; Matsubara, Satoshi Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 577 - 583

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Citation Number: 25

Abstract

In the present study, 2-(methylthio) pyrido [2, 3-d] pyri-midines having a variety of 4- alkylamino and 4-anilino side chains were prepared and their cytokinin agonistic and antagonistic activities were examined. Quantitative structure-activity analysis indicated that both series of compounds have a common mode of interaction with the receptor, and the maximum width of the N4 side chains, W,,, is an important factor in determining their ...