Bulletin of the Chemical Society of Japan

Kinetics and mechanism of decompositions of N-methyl-N'-aryl-N-nitrosoureas and related compounds in aqueous buffer solution.

K Yoshida, K Yano

Index: Yoshida, Kitaro; Yano, Kazuyuki Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 7 p. 2200 - 2203

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Citation Number: 13

Abstract

The decomposition reactions of N-methyl-N′-aryl-N-nitrosoureas (1) and of N, N′-dimethyl- N′-aryl-N-nitrosoureas (2) were studied kinetically in phosphate buffer solution. All nitrosoureas 1 were easily hydrolyzed even under neutral conditions and the rates of hydrolysis were found to be proportional to the hydroxide ion concentration over pH range 5.4–7.6. General base catalysis by buffer components was negligible. The reaction was ...