Chiral synthetic intermediates via asymmetric hydrogenation of. alpha.-methyl-. alpha.,. beta.-unsaturated aldehydes by bakers' yeast

P Gramatica, P Manitto, L Poli

Index: Gramatica, Paola; Manitto, Paolo; Poli, Laura Journal of Organic Chemistry, 1985 , vol. 50, # 23 p. 4625 - 4628

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Citation Number: 48

Abstract

Microbial-mediated reactions are a useful means of preparing chiral intermediates for synthetic studies.'The enantioselective microbial hydrogenation of the double bond in or P- methyl-a,@-unsaturated aldehydes3 (or alcohols or acetals) is well documented: Common baker's yeast appears to be particularly versatile and is easy to use for this purpose.