Bioorganic & medicinal chemistry letters

Synthesis and antitumor activity of 10-substituted benzylidene anthrone

W Hu, W Zhou

Index: Hu, Weixiao; Zhou, Wei Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 621 - 622

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Citation Number: 11

Abstract

Fifteen compounds of 10-substituted benzylidene anthrone were prepared with moderate yield by reaction of anthrone and substituted benzaldehydes under the presence of pyridine and piperidine as catalyst. Their antitumor activities in vitro were evaluated. The results show that the electron-withdrawing substitutes decrease the activities, the electron-donor substitutes increase the activities; the compound with substitute at ortho or para position ...